Catalog Number - 40031-PG6

40031-PG6 Cogent UDA™ (WCX) Guard Column Starter Set provides a convenient entry solution for protecting analytical HPLC columns while maintaining the unique mixed‑mode selectivity of the UDA™ stationary phase.

This set includes a Cogent Guard Column Holder and UDA™ (WCX) guard cartridge(s) packed with 4 µm, 100 Å TYPE‑C™ silica, ensuring full compatibility with UDA™ analytical column methods.

The UDA™ ligand (Undecanoic Acid) consists of an 11‑carbon hydrophobic chain with a terminal carboxylic acid group, enabling:

• Reversed phase (hydrophobic interactions)

• Weak cation exchange (active at pH ≥ 6)

• HILIC (polar interaction capability)

This matched mixed‑mode chemistry ensures contaminants are trapped effectively without altering chromatographic selectivity, maintaining accuracy and reproducibility.

Each cartridge is constructed from stainless steel tubing with stainless steel frits and is individually packaged in a protective Delrin case to prevent drying and damage.

3.0–4.6 mm ID Compatibility – Analytical HPLC Protection

• Designed for 3.0 mm, 4.0 mm, and 4.6 mm ID analytical columns

• Protects against particulates and strongly retained contaminants

• Maintains peak shape, efficiency, and resolution

• Extends analytical column lifetime

✅ Recommended for routine analytical HPLC workflows and method development

Flexible Use – Single Set Option

This configuration provides flexibility for smaller volume users or method development scenarios.

• Ideal when a full 5‑pack is not required

• Useful for testing guard column use or mixed‑phase strategies

• Supports pairing different guard chemistries with analytical columns

✅ Recommended for labs optimizing methods or evaluating selectivity differences

Flow Rate & System Requirements (4.0 mm ID format, 4 µm)

✅ Compatible with standard analytical HPLC systems

• Typical flow rate range: ~0.8 – 1.5 mL/min

• Moderate backpressure

• Suitable for UV and MS detectors

• Minimal impact on system pressure

✅ Best Practice: Replace cartridges as needed to maintain consistent performance

Why Use UDA™ Guard Columns

Column Protection

• Prevents particulate contamination

• Reduces buildup of strongly retained compounds

Maintains Selectivity

• Matched UDA™ chemistry preserves RP, WCX, and HILIC behavior

Improves Efficiency

• Extends column life

• Reduces downtime and replacement costs

TYPE‑C Silica Advantages

Faster Equilibration

• Reduces time between runs

No Strict Moisture Control (HILIC)

• Simplifies mobile phase preparation

Extreme Robustness

• Stable under low pH (<2) conditions

• Resistant to hydrolysis

Durable Construction

• Long service life in routine use

Cogent UDA™ Guard Kit Advantages

Complete Starter Solution

• Includes holder and cartridge(s)

Matched Mixed‑Mode Chemistry

• Seamless compatibility with UDA™ analytical columns

Flexible Usage

• Ideal for targeted applications or method development

Important Usage Notes

✅ Included Hardware: This starter set includes a Cogent Guard Column Holder, compatible with all Cogent guard column cartridges (view Cogent Guard Column Holder details and compatibility information)

• Designed for 3.0–4.6 mm ID analytical columns

• Replace cartridges as performance declines or pressure increases

• Store cartridges in protective cases when not in use

Use with guard column holder sold separately.